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Chondrocyte gene expression under applied surface motion .

A cartilage bioreactor has been designed that is intended to approximate the kinematics of natural joints and allows for functional cartilage tissue engineering studies. In particular, interface motion can be generated by oscillation of a ball over the surface of a construct. The present study investigated the specific effect of applied articular motion on the gene expression of chondrocytes .

Continuous passive motion applied to whole joints .

Continuous passive motion (CPM) is currently a part of patient rehabilitation regimens after a variety of orthopedic surgical procedures. While CPM can enhance the joint healing process, the direct effects of CPM on cartilage metabolism remain unknown. Recent in vivo and in vitro observations suggest that mechanical stimuli can regulate articular cartilage metabolism of proteoglycan 4 (PRG4 .

Tide Motion Bioreactor - Esco

Tide Motion Bioreactor Tide motion pertains to the oscillation of culture medium into and out of the matrix vessel that intermittently exposures the cells to aeration and nutrition. The upward oscillation exposes the cells to nutrition, while the downward oscillation exposes the cells to aeration and at the same time washes away products and .

Biostat® RM - Wave-Mixed Bioreactor | Sartorius

The Biostat® RM (Rocking Motion), is a fully GMP compliant, wave-mixed bioreactor. It is used with single-use Flexsafe® RM bags which are proven for a broad range of different cell lines incl. CHO, NS0, SF9, E.coli, stem cells and CAR-T cells.

Integrated Closed-Loop Step Motors From: Applied Motion .

Applied Motion Products solves heat problems associated with a peristaltic pump system that supplies materials to a bioreactor by replacing open-loop step motors with closed-loop step motors. A peristaltic pump, with internal tubing that separates media from pump components, offers a sanitary method to supply the bioreactor with various fluids .

Applied Motion - Articles, News and Companies related to .

Applied Motion Articles About Applied Motion. Articles are sorted by RELEVANCE. Sort by Date.. 1 Product NEws (October 2019). The complete Product News section from the October 2019 issue of Power Transmission Engineering, featuring new technologies from Timken, Applied Motion Products, LM76, Ogura, Portescap, Ruland Manufacturing, and Heidenhain 2 Product News (October 2008)

(PDF) Bag Bioreactor Based on Wave-Induced Motion .

Bag Bioreactor Based on Wa ve-Induced Motion 3.5 Residence Time Distribution Residence time is an important v alue with which to characterise continuously

Integrated closed-loop step motors solve bioreactor heat .

Applied Motion Products was approached to solve heat problems associated with a peristaltic pump system that supplies materials to a bioreactor by replacing open-loop step motors with its closed-loop step motors. A peristaltic pump, with internal tubing that separates media from pump components, offers a sanitary method to supply the bioreactor with various fluids to [.]

StepSERVO™ Integrated Motors Solve Heat . - Applied Motion

Applied Motion Products solved heat problems associated with a peristaltic pump system that supplies materials to a bioreactor by replacing open-loop step motors with closed-loop step motors. A peristaltic pump, with internal tubing that separates media from pump components, offers a sanitary method to supply the bioreactor with various fluids to grow cell cultures in the

Shear bioreactors stimulating chondrocyte regeneration, a .

2019-8-8 · In a similar study, the culture of human chondrocytes in bioreactor applied loading (0.1 MPa for 2 h) and perfusion (2 ml) led to increase of COL2A1 expression and decrease of COL1A1 and MMP-13 expression . Carmona-Moran and Wick applied perfusion bioreactor to promote chondrogenesis of human mesenchymal stem cells.

Integrated Closed-Loop Step Motors from Applied Motion .

A peristaltic pump, with internal tubing that separates media from pump components, offers a sanitary method to supply the bioreactor with various fluids to grow cell cultures in the development of new medicines. Step motors are used to drive the pump head, compressing and releasing the pump tubing to move media into the bioreactor chamber. Initially, excessive heat generated by open-loop step .

Disposable Bioreactors in Cell Culture-Based Upstream .

2020-8-18 · During the last 10 years, cost pressures and the changing requirements for bioreactors in the modern pharmaceutical industry have resulted in the increased use of disposable bioreactors in both R&D and manufacturing. Numerous studies have demonstrated their efficiency in cell culture-based upstream processing at small- and middle-volume scales. As shown in Figure 1, disposable .

bioreactor Archives - CPECN

Applied Motion Products was approached to solve heat problems associated with a peristaltic pump system that supplies materials to a bioreactor by replacing open-loop step motors with its .

Advantages of Closed-Loop Integrated Step Motors | Pumps .

2020-7-28 · Excessive heat generated by the open-loop step motors was elevating the temperature of the fluids pumped into the bioreactor, increasing biological process times and reducing yields. IMAGE 1: Peristaltic pumps feed fluids into bioreactor systems that grow cell cultures in the development of new medicines. (Images courtesy of Applied Motion .

Biostat® RM - Wave-Mixed Bioreactor | Sartorius

The Biostat® RM (Rocking Motion), is a fully GMP compliant, wave-mixed bioreactor. It is used with single-use Flexsafe® RM bags which are proven for a broad range of different cell lines incl. CHO, NS0, SF9, E.coli, stem cells and CAR-T cells.

Applied Motion Products, Inc. - Posts | Facebook

Applied Motion Products solved heat problems associated with a peristaltic pump system that supplies materials to a bioreactor by replacing open-loop step motors with closed-loop step motors. A peristaltic pump, with internal tubing that separates media from pump components, offers a sanitary method to supply the bioreactor with various fluids .

Axon Stretch Growth: The Mechanotransduction of Neuronal .

The automated linear motion table consists of a stepper motor (HT23-397, Applied Motion Products, Watsonville, CA) and linear motion table (MIPS-2-10-1.0mm, Servo Systems, Monteville, NJ) mounted to a delrin alignment table. The bioreactor chamber is seated within the table parallel to the linear motion .

motion control Archives - Sensors Daily

According to Applied Motion Products, "a peristaltic pump, with internal tubing that separates media from pump components, offers a sanitary method to supply the bioreactor with various fluids to grow cell cultures in the development of new medicines.

Oxygen Mass Transfer Correlation for a Rocking-Motion .

2020-8-16 · We applied the dynamic "gas-in, gas-out" method with bag compression for k L a determination as previously implemented by Yuk et al. for the study of a rocking-motion bioreactor (6). To facilitate oxygen transfer out of the medium, we opened a .

Bioreactors - an overview | ScienceDirect Topics

Bioreactors. A bioreactor can be defined as a system in which the conditions are closely controlled with respect to physiological conditions to induce certain behavior .

bioreactor Archives - CPECN

Applied Motion Products was approached to solve heat problems associated with a peristaltic pump system that supplies materials to a bioreactor by replacing open-loop step motors with its .

Sliding Motion in Filippov Differential Systems .

2018-9-18 · European Journal of Applied Mathematics 29:5, 757-777. (2018) Sliding motion and bifurcation in saline oscillator's model and liquid's density measurement using saline oscillator. Chaos, Solitons & Fractals 114, 321-331.

Applied Motion Products | Automation World

Applied Motion Products offers a series of integrated motors featuring multi-turn TruCount™ absolute encoders that do not require batteries or external power to track position when the motor is powered off. . Open-loop motors previously working in this system elevated the temperature of fluids being pumped into the bioreactor. The higher .

Disposable Bioreactors in Cell Culture-Based Upstream .

2020-8-18 · During the last 10 years, cost pressures and the changing requirements for bioreactors in the modern pharmaceutical industry have resulted in the increased use of disposable bioreactors in both R&D and manufacturing. Numerous studies have demonstrated their efficiency in cell culture-based upstream processing at small- and middle-volume scales. As shown in Figure 1, disposable .

Oxygen Mass Transfer Correlation for a Rocking-Motion .

2020-8-16 · We applied the dynamic "gas-in, gas-out" method with bag compression for k L a determination as previously implemented by Yuk et al. for the study of a rocking-motion bioreactor (6). To facilitate oxygen transfer out of the medium, we opened a .

US Patent for Method and apparatus for cultivating cells .

An apparatus for cultivating cells utilizing wave motion comprising a container, a retaining member configured to retain the container, a drive assembly for swiveling the container with respect to the substantially horizontal pivot axis and to swivel, such that during swiveling the pivot axis follows a cyclical closed-loop path.

Integrated Closed-Loop Step Motors Solve Heat Problems in .

Applied Motion Products—a supplier of high-precision, cost-effective motion control products including stepper and servo motors, drives, controllers, gearheads, and power supplies — says it has developed a system to control heat problems associated with a peristaltic pump system that supplies materials to a bioreactor by replacing open-loop step motors with closed-loop step motors.

bioreactor Archives - CPECN

Applied Motion Products was approached to solve heat problems associated with a peristaltic pump system that supplies materials to a bioreactor by replacing open-loop step motors with its .

Verification New Flexsafe STR Single-Use .

2014-12-9 · We further expanded the cells in 5-L (n – 3) and 25-L (n – 2) working volumes using a BIOSTAT RM rocking-motion bioreactor. The last seed expansion step — at 200 L in a BIOSTAT STR 200 (n – 1) system — generated the required inoculum volume of ~100 L for the large-scale run.

Shop All Single-Use Bioreactors | Thermo Fisher Scientific

This 2000 L Thermo Scientific 5:1 Single-Use Bioreactor (SUB) is water-jacketed and includes AC motor, 240VAC, e-box, and analog load cells. It is designed using traditional stainless-steel bioreactor principles to ensure optimal cell culture performance.